Skip to main content

Fundamentals

Your journey toward understanding wellness in the workplace begins with a question of profound personal significance. When your employer offers a wellness program, your participation is framed as a choice.

The Americans with Disabilities Act (ADA) provides a legal definition for what makes this choice truly “voluntary.” This framework is built upon the principle that your health information is private and your engagement in any health-related activity must be of your own volition. An employer cannot require you to participate, deny you health coverage for declining, or take any adverse action against you for your decision. This legal standard is the baseline for protecting your autonomy.

This concept of autonomy, however, extends deep within your own biology. True voluntary action originates from a state of physiological balance, a condition where your body’s internal communication systems are functioning with clarity and precision. Your endocrine system, a sophisticated network of glands and hormones, is the master regulator of this internal environment.

Hormones are chemical messengers that travel through your bloodstream, instructing tissues and organs on how to respond to everything from the food you eat to the stress you experience. They govern your energy levels, your mood, your cognitive function, and your capacity to make clear, reasoned decisions. When this system is in a state of equilibrium, or homeostasis, you operate from a foundation of stability. Your ability to choose is clear and unclouded.

A truly voluntary choice requires both legal protection from external coercion and a state of internal biological stability.

The challenge arises when this internal stability is disrupted. Chronic stress, poor nutrition, lack of sleep, or underlying health conditions can create significant hormonal dysregulation. This is where the legal definition of “voluntary” meets the lived reality of your physical and mental state.

A person experiencing the profound fatigue of an underactive thyroid, the cognitive fog of low testosterone, or the emotional lability of perimenopausal fluctuations perceives the world through a different biological lens. From this perspective, a workplace wellness initiative, even one that meets the basic legal standards, can feel like an immense burden. The pressure to engage, to track metrics, and to meet health targets becomes another significant stressor, further disrupting the very systems the program is ostensibly designed to support.

A textured root, symbolizing the foundational endocrine system, supports precise layers of bioidentical hormone slices and advanced peptide protocols. This structured approach signifies personalized medicine for hormonal homeostasis, guiding optimal metabolic health and addressing Hypogonadism or Perimenopause

What Is the Body’s Core Communication Network?

At the heart of your ability to respond to your environment is the intricate dialogue between your brain and your endocrine glands. This communication network, primarily orchestrated by the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-gonadal (HPG) axis, dictates how you adapt to challenges.

The HPA axis is your primary stress-response system. When faced with a perceived threat ∞ be it a physical danger or a demanding work deadline ∞ your hypothalamus releases corticotropin-releasing hormone (CRH). This signals your pituitary gland to release adrenocorticotropic hormone (ACTH), which in turn instructs your adrenal glands to produce cortisol.

In short bursts, cortisol is vital; it sharpens focus and mobilizes energy. When stress becomes chronic, however, continuously elevated cortisol creates systemic disruption, impacting sleep, metabolism, and cognitive function. This state of chronic activation compromises your capacity for calm, reasoned choice.

Simultaneously, the HPG axis governs your reproductive and metabolic health. The hypothalamus releases gonadotropin-releasing hormone (GnRH) in a pulsatile rhythm, signaling the pituitary to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones then act on the gonads (testes in men, ovaries in women) to produce testosterone and estrogen.

These sex hormones are fundamental to much more than reproduction; they are critical for maintaining muscle mass, bone density, cognitive clarity, and a stable mood. When the delicate signaling of the HPG axis is disturbed by factors like age, stress, or environmental toxins, the resulting hormonal deficiencies create symptoms that directly undermine your sense of well-being and personal agency.

Understanding this biological architecture is the first step in appreciating that the decision to participate in a wellness program is never made in a vacuum. It is made by a complex, interconnected system profoundly influenced by its own internal chemistry.


Intermediate

The Equal Employment Opportunity Commission (EEOC) provides specific guidance on the ADA’s definition of “voluntary.” For a wellness program that includes medical questions or examinations to be considered voluntary, it must be “reasonably designed to promote health or prevent disease.” This means the program must have a reasonable chance of improving health, must not be overly burdensome, and cannot be a subterfuge for discrimination.

A key component of this guidance relates to incentives. The EEOC has stipulated that any incentive offered cannot be so large as to be coercive. For many years, this was tied to a specific financial threshold ∞ up to 30% of the total cost of self-only health insurance coverage. The logic is that an excessively large reward or penalty could compel an employee to disclose sensitive health information against their better judgment, thus rendering their participation involuntary.

This legal and financial framework, while clear on paper, interacts in complex ways with an individual’s endocrine and metabolic health. Many corporate wellness programs focus on a standard set of biometric markers ∞ Body Mass Index (BMI), blood pressure, cholesterol levels, and blood glucose. From a purely clinical perspective, these are valuable data points.

Their interpretation, however, is deeply dependent on the individual’s underlying hormonal status. A program that applies uniform pressure to achieve specific targets across a diverse workforce, without accounting for these individual biological contexts, can inadvertently become a source of physiological distress.

The very act of being measured against a generic standard can activate the body’s stress response system, the HPA axis, leading to an increase in cortisol production. Chronically elevated cortisol directly undermines the goals of a wellness program. It promotes visceral fat storage, increases blood pressure, disrupts insulin signaling, and can lead to elevated blood glucose. In essence, the pressure to “be well” according to a standardized chart can make an individual’s biochemistry unwell.

A pristine white dahlia displays intricate, layered petals, symbolizing precise hormonal balance and metabolic optimization. Its symmetrical structure reflects personalized medicine, supporting cellular health and comprehensive endocrine system homeostasis, vital for regenerative medicine and the patient journey

How Do Hormonal Realities Intersect with Program Metrics?

Consider the distinct hormonal realities of different individuals within a workforce. A 45-year-old man experiencing the gradual decline of testosterone associated with andropause may struggle with fatigue, weight gain around the midsection, and a decline in motivation. His elevated BMI and borderline high cholesterol are direct symptoms of his underlying endocrine condition.

For him, a wellness program’s focus on diet and exercise alone, without addressing the foundational testosterone deficiency, is unlikely to yield significant results. The demand to participate and the potential financial penalty for failing to meet certain metrics can feel punitive, adding psychological stress to his existing physiological burden. His participation, compelled by financial pressure in the face of insurmountable biological hurdles, is voluntary only in the thinnest legal sense.

Similarly, a 48-year-old woman navigating perimenopause experiences fluctuating levels of estrogen and progesterone. These fluctuations can lead to irregular sleep, hot flashes, mood swings, and changes in body composition. Her ability to regulate blood sugar can become less efficient, and she may find it harder to maintain her previous weight.

When she is asked to participate in a wellness program that measures her fasting glucose and BMI, the results may be discouraging. The program’s design may not recognize that her metabolic changes are a consequence of a natural but challenging hormonal transition.

The requirement to share this data, and the pressure to “correct” it through standard interventions, fails to acknowledge the root cause. Her participation is predicated on a system that does not see her, and the experience can feel invalidating and coercive.

A wellness program’s design must account for the biological realities of its participants to be truly voluntary and effective.

This disconnect between a program’s design and an individual’s biology is where the concept of “voluntary” becomes most strained. The table below juxtaposes the EEOC’s legal standards with the lived biological experience of an individual with a common hormonal imbalance, illustrating the potential for coercion even within a legally compliant framework.

EEOC Legal Standard for “Voluntary” Biological Reality for an Individual with Hypothyroidism
Participation is not required. An employer cannot force an employee to join the program. The individual experiences profound fatigue, cognitive slowness, and depression. The mental and physical energy required to even consider, let alone engage with, a new program is immense. The choice to abstain is driven by symptom burden, not free will.
No denial of health insurance or benefits. An employer cannot limit coverage for non-participation. While insurance is not denied, the financial incentive (e.g. a premium reduction) for participation can feel like a penalty for non-participation. For someone whose earning capacity may already be affected by their symptoms, this financial pressure is a powerful coercive force.
No adverse employment action. An employer cannot fire or demote an employee for not participating. The individual may fear being perceived as “unhealthy” or “uncommitted” by management if they decline to participate. This perceived social and professional risk can compel participation to avoid potential unspoken consequences.
Program must be reasonably designed. The program should not be overly burdensome. For an individual with untreated hypothyroidism, requirements like attending weekly meetings, tracking daily calories, or committing to a new exercise regimen are exceptionally burdensome. The program’s design, seen as reasonable for a healthy person, is a significant obstacle.

Addressing this gap requires a more sophisticated approach. Personalized wellness protocols, such as Testosterone Replacement Therapy (TRT) for men with clinically low levels, or bioidentical hormone support for women in perimenopause, work by restoring the body’s foundational chemistry. These interventions are not about simply chasing biometric targets.

They are about re-establishing the physiological stability that is a prerequisite for genuine health and autonomous choice. When a man’s testosterone is optimized, his energy, motivation, and ability to build muscle and lose fat are restored. When a woman’s hormonal fluctuations are stabilized, her sleep, mood, and metabolic function improve.

From this restored state of being, the decision to engage in healthy behaviors ∞ to eat well, to exercise, to manage stress ∞ becomes an authentic, internally-driven choice. It is from this place of biological resilience that participation in a wellness program can become truly voluntary and genuinely beneficial.


Academic

The interaction between a workplace wellness program and an employee is a complex event in psychoneuroendocrinology. The ADA’s legal standard of “voluntary” participation can be analyzed through the lens of allostasis and allostatic load, concepts articulated by researchers like Bruce McEwen. Allostasis refers to the process of maintaining physiological stability, or homeostasis, through adaptation.

The body’s stress response systems, particularly the hypothalamic-pituitary-adrenal (HPA) axis, are central to this adaptive process. Allostatic load represents the cumulative physiological wear and tear that results from chronic or poorly regulated activation of these systems. A wellness program that is perceived as coercive, demanding, or judgmental becomes a significant psychosocial stressor, contributing directly to an individual’s allostatic load.

This process begins with the appraisal of the program by the individual. If the program’s requirements (e.g. achieving a certain BMI, lowering blood pressure by a set amount) are perceived as unattainable due to an underlying, unaddressed physiological condition such as insulin resistance or gonadal steroid deficiency, the individual experiences a state of chronic, non-resolving stress.

This perception of a challenge that exceeds one’s coping capacity triggers a cascade of neuro-hormonal events. The amygdala, the brain’s threat-detection center, signals the hypothalamus to initiate the HPA axis response. The sustained release of cortisol and catecholamines (epinephrine and norepinephrine) has widespread effects. In the short term, this is adaptive.

Chronically, it is pathogenic. Sustained cortisol exposure can induce glucocorticoid receptor resistance in the brain, particularly in the hippocampus and prefrontal cortex. This impairs the negative feedback mechanism that normally shuts off the stress response, leading to a state of hypercortisolemia and further dysregulation. The consequences manifest as impaired cognitive function, mood disturbances, immune suppression, and a worsening of the very metabolic markers the wellness program aims to improve.

A white tulip-like bloom reveals its intricate core. Six textured, greyish anther-like structures encircle a smooth, white central pistil

What Is the Systemic Impact of Coercive Wellness?

The impact of a coercive wellness program extends beyond the HPA axis, creating a cascade of systemic dysfunction. The intricate crosstalk between the body’s major regulatory axes means that a disruption in one system inevitably affects the others. The hypothalamic-pituitary-gonadal (HPG) axis is particularly sensitive to stress-induced disruptions.

Elevated levels of CRH and cortisol can suppress the pulsatile release of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus. This suppression leads to decreased production of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) by the pituitary. The downstream effect is a reduction in gonadal steroidogenesis ∞ decreased testosterone production in men and disrupted estrogen and progesterone cycles in women.

This condition, known as functional hypogonadism, produces symptoms ∞ fatigue, depression, loss of libido, decreased muscle mass, increased adiposity ∞ that are often the very targets of wellness interventions. A program that induces this state through psychosocial stress is, therefore, operating at cross-purposes to its stated goals. It is creating a biological environment that makes compliance with its own demands physiologically untenable.

A wellness program perceived as coercive can become a pathogenic stressor, increasing allostatic load and paradoxically worsening health outcomes.

Furthermore, the interplay between stress hormones and metabolic hormones is critical. High cortisol levels promote gluconeogenesis in the liver and increase insulin resistance in peripheral tissues. This forces the pancreas to secrete more insulin to maintain euglycemia, leading to hyperinsulinemia. This state is a primary driver of metabolic syndrome, characterized by hypertension, dyslipidemia, and central obesity.

A wellness program that focuses narrowly on caloric intake and expenditure, without addressing the underlying hormonal drivers of metabolic dysfunction, fails to address the root cause. For an individual already struggling with insulin resistance, the added stress of the program can exacerbate their condition, making weight loss and metabolic control even more difficult.

A thoughtful male patient embodying clinical wellness, showcasing optimal hormonal balance, improved metabolic health, and robust cellular function from a comprehensive, evidence-based peptide therapy protocol, highlighting therapeutic efficacy.

Can Therapeutic Protocols Restore Biological Autonomy?

From a systems biology perspective, restoring the capacity for voluntary health engagement requires interventions that re-establish homeostatic regulation at a fundamental level. This is the role of advanced therapeutic protocols, including hormonal optimization and peptide therapies. These interventions are designed to correct the specific biochemical deficits that contribute to high allostatic load and diminished personal agency. They create the physiological foundation upon which meaningful, self-directed health choices can be built.

The following table outlines several key peptide therapies and their mechanisms of action, illustrating how they target specific points within the dysregulated neuroendocrine systems to restore function.

Peptide Therapy Mechanism of Action Contribution to Biological Autonomy
Sermorelin / CJC-1295 These are Growth Hormone Releasing Hormone (GHRH) analogs. They stimulate the pituitary gland to produce and release the body’s own growth hormone (GH) in a natural, pulsatile manner. By restoring a more youthful GH profile, these peptides can improve sleep quality, enhance recovery, reduce body fat, and increase lean muscle mass. This leads to increased energy and vitality, directly combating the fatigue and physical decline that can make health initiatives feel burdensome.
Ipamorelin A Growth Hormone Secretagogue Receptor (GHS-R) agonist and a ghrelin mimetic. It selectively stimulates GH release from the pituitary with minimal effect on cortisol or prolactin levels. Provides a clean, targeted stimulus for GH release. Improved sleep architecture and physical recovery enhance cognitive function and mood, creating a greater capacity for proactive health management.
Tesamorelin A synthetic GHRH analog specifically studied and approved for the reduction of visceral adipose tissue (VAT) in certain populations. Directly targets the pathogenic visceral fat that is a hallmark of metabolic syndrome and HPA axis dysfunction. By reducing this metabolically active fat, it improves insulin sensitivity and reduces systemic inflammation, addressing a core component of allostatic load.
PT-141 (Bremelanotide) A melanocortin receptor agonist that acts within the central nervous system to influence pathways associated with sexual arousal and motivation. Restores function in a domain profoundly affected by stress-induced HPG axis suppression. By addressing issues of libido and sexual health, it can improve quality of life, mood, and partner intimacy, which are foundational aspects of overall well-being.

These protocols, alongside carefully managed Testosterone Replacement Therapy (TRT) for men with diagnosed hypogonadism or Hormone Therapy (HT) for symptomatic menopausal women, represent a clinical strategy focused on restoring systemic integrity. The objective is to shift the body from a state of high allostatic load and compromised function to a state of resilience and homeostatic balance.

An individual whose sleep is restorative, whose metabolic function is efficient, and whose hormonal milieu supports stable energy and mood is biologically equipped to make voluntary choices. They can engage with health-promoting behaviors not because of an external financial incentive, but because it aligns with their internal state of well-being. In this context, the ADA’s requirement for “voluntary” participation is fulfilled at its deepest level ∞ the biological capacity for autonomous, self-directed action has been restored.

A tree trunk exhibits distinct bark textures. Peeling white bark symbolizes restored hormonal balance and cellular regeneration post-HRT

References

  • McEwen, B. S. (2017). Neurobiological and Systemic Effects of Chronic Stress. Chronic Stress (Thousand Oaks, Calif.), 1, 2470547017692328.
  • Anawalt, B. D. & Bhasin, S. (2018). Testosterone Therapy in Men With Androgen Deficiency Syndromes ∞ An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, 103(5), 1715 ∞ 1744.
  • Sapolsky, R. M. Romero, L. M. & Munck, A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews, 21(1), 55 ∞ 89.
  • The NAMS 2022 Hormone Therapy Position Statement Advisory Panel. (2022). The 2022 hormone therapy position statement of The North American Menopause Society. Menopause (New York, N.Y.), 29(7), 767 ∞ 794.
  • Sigalos, J. T. & Pastuszak, A. W. (2018). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 6(1), 45 ∞ 53.
  • U.S. Equal Employment Opportunity Commission. (2016). Final Rule on Employer Wellness Programs and the Americans with Disabilities Act. 29 C.F.R. § 1630.14(d).
  • Winston & Strawn LLP. (2016). EEOC Issues Final Rules on Employer Wellness Programs.
  • Society for Human Resource Management. (2021). EEOC Proposes ∞ Then Suspends ∞ Regulations on Wellness Program Incentives.
Healthy man and woman display patient outcomes from hormone optimization. Their balanced appearance signifies successful endocrine balance, enhanced metabolic health, and optimal cellular function, achieved via tailored clinical protocols and peptide therapy

Reflection

You have now examined the legal architecture of “voluntary” participation and the intricate biological systems that define your personal autonomy. The knowledge that your internal state ∞ your hormonal balance, your stress response, your metabolic health ∞ is the true author of your choices is a profound realization.

This understanding shifts the focus from external compliance to internal calibration. The question becomes less about the rules of a program and more about the readiness of your own system to engage. Consider your own body’s signals. The persistent fatigue, the subtle shifts in mood, the creeping weight gain ∞ these are not character flaws.

They are data points. They are messages from a complex, intelligent system that is doing its best to adapt to the pressures of its environment. What is your biology telling you about your capacity for choice right now? The path forward begins not with a wellness program, but with a deep and honest listening to the wisdom of your own body.

This is the starting point for reclaiming a state of being from which all your choices can be truly your own.

A mature man reading by a window embodies serene patient well-being and enhanced cognitive health. This clinical wellness scene suggests successful hormone optimization, promoting robust metabolic health, improved cellular function, and optimal endocrine balance through targeted therapeutic protocols

Glossary

A smooth, light green torus and delicate botanicals symbolize Hormonal Homeostasis and the Patient Journey in Hormone Replacement Therapy. This represents precise Bioidentical Hormone and Peptide Protocols for Metabolic Optimization, fostering Reclaimed Vitality and addressing Hypogonadism or Perimenopause

wellness program

Meaning ∞ A Wellness Program represents a structured, proactive intervention designed to support individuals in achieving and maintaining optimal physiological and psychological health states.
A poised individual embodies radiant metabolic health and balanced endocrine function. This portrait suggests optimal cellular regeneration, achieved through personalized peptide therapy and effective clinical protocols, fostering patient well-being

americans with disabilities act

Meaning ∞ The Americans with Disabilities Act (ADA), enacted in 1990, is a comprehensive civil rights law prohibiting discrimination against individuals with disabilities across public life.
Individuals in a tranquil garden signify optimal metabolic health via hormone optimization. A central figure demonstrates improved cellular function and clinical wellness, reflecting a successful patient journey from personalized health protocols, restorative treatments, and integrative medicine insight

cognitive function

Meaning ∞ Cognitive function refers to the mental processes that enable an individual to acquire, process, store, and utilize information.
A serene woman embodying the vibrant therapeutic outcomes of hormone optimization and metabolic health. Her composed gaze reflects a successful patient journey, highlighting clinical wellness, endocrine balance, and robust cellular regeneration achieved through personalized protocols

chronic stress

Meaning ∞ Chronic stress describes a state of prolonged physiological and psychological arousal when an individual experiences persistent demands or threats without adequate recovery.
A serene individual, eyes closed, embodies the profound peace of successful hormone optimization. This reflects improved metabolic health, robust cellular function, and positive therapeutic outcomes from personalized peptide therapy, fostering patient well-being, endocrine balance, and stress adaptation

cortisol

Meaning ∞ Cortisol is a vital glucocorticoid hormone synthesized in the adrenal cortex, playing a central role in the body's physiological response to stress, regulating metabolism, modulating immune function, and maintaining blood pressure.
Adult woman and child signify hormone optimization benefits. This depicts a wellness journey through patient-centered care, enhancing metabolic health, cellular function, endocrine system balance, and vitality restoration

hpa axis

Meaning ∞ The HPA Axis, or Hypothalamic-Pituitary-Adrenal Axis, is a fundamental neuroendocrine system orchestrating the body's adaptive responses to stressors.
Male patient's clear complexion and poised demeanor embody optimal physiological balance from hormone optimization. These visual markers signify improved metabolic health and cellular function, underscoring positive clinical outcomes through a targeted TRT protocol or peptide therapy for patient well-being

hpg axis

Meaning ∞ The HPG Axis, or Hypothalamic-Pituitary-Gonadal Axis, is a fundamental neuroendocrine pathway regulating human reproductive and sexual functions.
A focused patient profile embodies hormone optimization benefits. This visual signifies achieved metabolic health, refined endocrine balance, and improved cellular function through personalized treatment, culminating in profound vitality and successful patient journey towards clinical wellness

equal employment opportunity commission

Meaning ∞ The Equal Employment Opportunity Commission, EEOC, functions as a key regulatory organ within the societal framework, enforcing civil rights laws against workplace discrimination.
A radiant complexion highlights profound cellular vitality and optimal endocrine balance. This illustrates successful metabolic health and positive patient outcomes, signifying evidence-based clinical wellness protocols

wellness programs

Meaning ∞ Wellness programs are structured, proactive interventions designed to optimize an individual's physiological function and mitigate the risk of chronic conditions by addressing modifiable lifestyle determinants of health.
A man's composed visage in natural light portrays achieved endocrine balance and robust metabolic health. He exemplifies the patient journey of hormone optimization, reflecting enhanced cellular function, improved physiological vitality, and positive clinical outcomes from advanced protocols

stress response

Meaning ∞ The stress response is the body's physiological and psychological reaction to perceived threats or demands, known as stressors.
A woman's serene expression reflects optimal endocrine health, showcasing successful hormone optimization and metabolic balance. Her vitality suggests positive therapeutic outcomes from personalized clinical protocols, emphasizing patient engagement

coercion

Meaning ∞ Coercion, within a clinical framework, denotes the application of undue pressure or external influence upon an individual, compelling a specific action or decision, particularly regarding their health choices or physiological management.
Focused lips indicate active patient consultation, revealing a supportive clinical environment. This setting facilitates discussions on hormone optimization, metabolic health, and functional wellness, guiding therapeutic protocols for an optimal patient journey towards endocrine balance

testosterone replacement therapy

Meaning ∞ Testosterone Replacement Therapy (TRT) is a medical treatment for individuals with clinical hypogonadism.
A balanced vertical composition of a pear, layered pastel discs, and a split lime revealing intricate white spheres. This visually embodies the precise, multi-faceted approach of Hormone Replacement Therapy

personalized wellness

Meaning ∞ Personalized Wellness represents a clinical approach that tailors health interventions to an individual's unique biological, genetic, lifestyle, and environmental factors.
A mature individual looks serenely skyward, embodying successful hormone optimization and profound metabolic health. This image symbolizes a patient's positive wellness journey post-clinical protocols, achieving optimal cellular function and endocrine balance, indicative of profound restorative well-being and bio-regulation

metabolic function

Meaning ∞ Metabolic function refers to the sum of biochemical processes occurring within an organism to maintain life, encompassing the conversion of food into energy, the synthesis of proteins, lipids, nucleic acids, and the elimination of waste products.
A young woman radiates patient well-being in sunlight, a symbol of successful hormone optimization and cellular regeneration. Her peaceful state reflects an effective clinical protocol, contributing to metabolic health, endocrine balance, vitality restoration, and overall health optimization

allostatic load

Meaning ∞ Allostatic load represents the cumulative physiological burden incurred by the body and brain due to chronic or repeated exposure to stress.
A male subject with healthy complexion and clear gaze, reflecting optimal endocrine balance and metabolic health. This visually signifies successful hormone optimization, improved cellular function, and enhanced patient well-being from comprehensive clinical wellness protocols

insulin resistance

Meaning ∞ Insulin resistance describes a physiological state where target cells, primarily in muscle, fat, and liver, respond poorly to insulin.