A specific intensity level of cardiovascular exercise where the heart rate is maintained at approximately 60% to 70% of the individual’s maximum heart rate, corresponding to an effort level where conversation is possible but slightly strained. Physiologically, this intensity is characterized by the body’s maximal capacity to utilize fat as the primary fuel source and is the most efficient zone for stimulating mitochondrial biogenesis. It is a cornerstone of metabolic health and endurance conditioning.
Origin
This term originates from exercise physiology and sports science, where training intensity is often divided into five “zones” based on heart rate or lactate threshold to prescribe precise exercise loads. Zone 2 specifically targets the high end of the aerobic metabolism range.
Mechanism
The primary mechanism for Zone 2 training is the chronic activation of AMPK (AMP-activated protein kinase), which serves as a master regulator of cellular energy homeostasis. This activation signals the cell to increase the transcription of genes responsible for mitochondrial protein synthesis, leading to an increase in the number and efficiency of mitochondria. This enhancement improves the cell’s capacity for oxidative phosphorylation, leading to superior fat utilization and improved insulin sensitivity, directly impacting metabolic and hormonal health.
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