What is the Origin of Zinc Thymulin?

The peptide thymulin was originally isolated from the thymus, and its zinc dependence was established shortly thereafter, leading to the designation 'Zinc Thymulin' to denote the active complex. This discovery linked the endocrine function of the thymus directly to the essential trace element zinc. The concept is central to nutritional immunology and the study of age-related immune decline, or immunosenescence.

What is the Mechanism of Zinc Thymulin?

The zinc atom is chelated by the peptide, which allows the resulting molecule to bind to specific receptors on T-lymphocytes, the key orchestrators of cellular immunity. This binding initiates the signaling cascade necessary for T-cell proliferation, differentiation into helper and cytotoxic cells, and overall immune system surveillance. Zinc deficiency can render thymulin biologically inert, severely impairing T-cell-mediated immunity and immune competence.

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Zinc Thymulin

Meaning

Zinc Thymulin is the biologically active form of the thymic hormone thymulin, where the peptide is complexed with a zinc atom. Thymulin is a nonapeptide hormone secreted by the thymus gland that is essential for T-cell differentiation and maturation, playing a critical role in adaptive immune function. The binding of zinc is absolutely necessary for the hormone to acquire its functional conformation and exert its vital immunoregulatory effects.

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Zinc Thymulin

Meaning

Origin

Mechanism

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