The proactive, integrated, and evidence-based strategy of clinical interventions, lifestyle modifications, and personalized supplementation aimed at decelerating the rate of biological aging and optimizing physiological function to a level associated with a younger chronological age. This pursuit is a comprehensive approach to longevity, focusing on maintaining the youthful integrity of cellular, metabolic, and endocrine systems. It is the active engagement in maximizing healthspan.
Origin
This term is a philosophical and clinical construct within the modern longevity and anti-aging movement, signifying the deliberate effort to influence the aging process. It moves the focus from passively accepting age-related decline to actively managing the biological determinants of health and vitality. The pursuit is grounded in the science of cellular senescence and hormonal optimization.
Mechanism
The pursuit’s mechanism involves targeting the hallmarks of aging, such as mitochondrial dysfunction, telomere shortening, and chronic inflammation, through precise, data-driven interventions. This includes optimizing the endocrine profile—maintaining youthful hormone kinetics—to support tissue repair and metabolic homeostasis. By continuously correcting system-level drift, the pursuit aims to keep biological age significantly lower
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