Youthful Physiological Range defines a constellation of biomarker values—hormonal, metabolic, and cellular—that statistically and functionally align with optimal health observed in young, vigorous individuals, irrespective of chronological age. This range represents peak biological efficiency and resilience. Clinically, we aim to guide an individual’s status toward these parameters for maximal vitality. It is a standard based on function, not just statistical normalcy.
Origin
This concept originates from comparative physiology, establishing an aspirational benchmark based on observed peak performance states in younger cohorts. It provides a clear, actionable target for longevity interventions.
Mechanism
Achieving this range requires optimizing the primary endocrine regulators, such as achieving optimal free testosterone, estradiol, and DHEA-S levels that support anabolic drive and cellular repair. Furthermore, robust mitochondrial function and efficient nutrient signaling must be present to support the high metabolic demands of a youthful physiological state. This integration ensures systemic energetic adequacy.
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