The optimal functioning of integrated physiological systems—including neuroendocrine signaling, mitochondrial efficiency, musculoskeletal strength, and cardiorespiratory capacity—that collectively define high-level physical and cognitive performance typically associated with younger individuals. The objective is to sustain and restore these core biological processes to extend healthspan and functional longevity.
Origin
This is a descriptive term combining gerontology, exercise physiology, and endocrinology, focusing on the underlying biological mechanisms of high performance across the lifespan.
Mechanism
Key mechanics include a robust anabolic hormonal environment (e.g., high growth hormone and testosterone pulsatility), high insulin sensitivity, efficient substrate utilization, and minimal systemic inflammation. Maintaining the integrity of the neuromuscular junction and promoting cellular repair pathways, such as autophagy, are also central to sustaining the functional capacity that underpins youthful performance.
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