A set of laboratory values that define the statistical range of physiological and biochemical markers, including hormones, lipids, and inflammatory factors, observed in a population of healthy individuals typically between the ages of 20 and 35. This range is utilized in advanced clinical practice as the aspirational target for optimal health and function in aging patients. It serves as a benchmark for biological youth. Achieving these levels is a primary therapeutic goal.
Origin
The concept is a clinical refinement of traditional, age-adjusted reference intervals, which often include values reflecting age-related decline. Longevity and performance medicine adopted this range to define a state of maximal vitality and functional capacity, moving the goalpost from merely “non-diseased” to “optimized.” This represents a philosophical shift in the definition of health.
Mechanism
By setting the therapeutic target to the young adult range, clinicians aim to restore the hormonal milieu and metabolic efficiency characteristic of peak physiological performance. Achieving these levels is believed to maximize receptor sensitivity, enhance anabolic signaling, and mitigate the age-related loss of tissue and organ function, thereby slowing biological aging. Precision dosing protocols are essential for safely attaining this optimal range.
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