Question 1

What is the Meaning of YAP/TAZ Pathway?

Accepted Answer

The YAP/TAZ Pathway refers to the transcriptional co-activators Yes-associated protein (YAP) and Transcriptional co-activator with PDZ-binding motif (TAZ), which are key downstream effectors of the Hippo signaling cascade. This pathway functions as a crucial cellular mechanotransducer, sensing mechanical cues and cell density to regulate organ size, cell proliferation, tissue regeneration, and apoptosis. Dysregulation of this signaling axis is frequently implicated in oncogenesis and developmental disorders.

Question 2

What is the Origin of YAP/TAZ Pathway?

Accepted Answer

The term is an acronym derived from the names of the two primary protein components, YAP and TAZ, and is recognized as a major regulatory axis in cell biology. Its discovery and characterization were central to understanding how cells integrate physical environmental cues into their genetic programs, linking tissue architecture directly to growth control.

Question 3

What is the Mechanism of YAP/TAZ Pathway?

Accepted Answer

The core mechanism involves the phosphorylation state of YAP and TAZ, which is regulated by the upstream Hippo kinase cascade. When the Hippo pathway is active, YAP and TAZ are phosphorylated, leading to their sequestration in the cytoplasm or degradation. Conversely, when the Hippo pathway is inactive, non-phosphorylated YAP and TAZ translocate to the nucleus, where they bind to transcription factors, most notably the TEAD family, to initiate the gene expression programs that drive cell growth and proliferation.

YAP/TAZ Pathway

Meaning

Origin

Mechanism

How Does Prolonged Pressure Affect Cellular Hormone Reception?

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