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Y-Chromosome Microdeletion

Meaning

Y-Chromosome Microdeletion is a specific genetic abnormality involving the loss of small segments of DNA from the long arm of the Y chromosome, most commonly affecting the Azoospermia Factor (AZF) regions. This deletion is a significant and frequent genetic cause of male infertility, leading to varying degrees of spermatogenic failure, from low sperm count to complete absence of sperm. Clinical diagnosis of this microdeletion is crucial for counseling men regarding their reproductive potential and considering assisted reproductive technologies.