The measurable decrease in the depth, length, and overall severity of facial and dermal creases, achieved through interventions that target the underlying structural and cellular components of the skin. This clinical endpoint is a quantifiable metric used in dermatological and cosmetic science to assess the efficacy of anti-aging treatments. True reduction requires addressing the causes of dermal atrophy and loss of elasticity.
Origin
This is a clinical and cosmetic metric derived from “Dermatology” and “Biometric Skin Analysis,” combining “Wrinkle Volume” for the three-dimensional measure of creases and “Reduction” for the desired therapeutic outcome.
Mechanism
The reduction mechanism centers on stimulating the synthesis of key dermal structural proteins, specifically collagen and elastin, by fibroblasts within the skin’s matrix. Interventions, such as topical retinoids or internal hormone support, can upregulate these processes, leading to increased dermal thickness and improved hydration. This cellular regeneration effectively plumps the skin from beneath, minimizing the visible topographical irregularities.
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