What is the Origin of Women's HRT?

HRT is an abbreviation for Hormone Replacement Therapy, a practice rooted in endocrinology aimed at restoring deficient endogenous hormone levels. Its application in women specifically addresses the decline in ovarian steroid production.

What is the Mechanism of Women's HRT?

The therapy mechanism involves supplying exogenous steroid hormones that bind to estrogen and progesterone receptors in target tissues like bone, cardiovascular endothelium, and the central nervous system. This binding restores normal physiological signaling, counteracting the negative effects of hormone withdrawal, such as bone mineral density loss or mood dysregulation linked to fluctuating receptor stimulation.

Women’s HRT

Meaning

Hormone Replacement Therapy specifically tailored for women, typically involving the administration of estrogen, often with progesterone, to mitigate symptoms associated with hypoestrogenism, such as menopausal vasomotor symptoms or premature ovarian insufficiency. Clinical application requires careful titration to balance symptom relief with minimizing risks associated with supra-physiological hormone levels.