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Wolff’s Law

Meaning

Wolff’s Law is a fundamental principle in orthopedic and bone physiology stating that bone in a healthy person or animal will adapt to the loads under which it is placed. Specifically, the internal architecture and external shape of the bone will remodel itself over time to efficiently resist the stresses applied to it, a process crucial for maintaining skeletal strength and density throughout the lifespan. This adaptive process is heavily influenced by the endocrine environment, particularly the balance of calcium-regulating hormones and sex steroids.