What is the Origin of WNT4?

The WNT family of genes, of which WNT4 is a member, is an evolutionarily ancient signaling system initially discovered for its role in regulating cell fate, polarity, and embryonic development. Its specific function in mammalian sex determination and ovarian maintenance is a critical area of reproductive endocrinology.

What is the Mechanism of WNT4?

The WNT4 protein operates by binding to its cognate Frizzled receptors on target cells, activating the canonical WNT/beta-catenin signaling pathway, which controls the transcription of genes essential for ovarian development. Crucially, WNT4 actively suppresses the production and function of male sex hormones (androgens) by inhibiting the enzyme 5-alpha reductase, thereby facilitating the development of the Müllerian ducts into the uterus and fallopian tubes.

WNT4 ∞ Area

WNT4

Meaning

WNT4 is a gene that provides instructions for synthesizing the WNT4 protein, a secreted signaling molecule that is essential for the proper development of the female reproductive system and the physiological regulation of steroidogenesis. It acts as a key molecular switch, promoting female development while simultaneously repressing the pathways for male sexual differentiation.