The precise process of establishing and maintaining the temporal boundaries and internal physiological readiness for the daily active phase, which is orchestrated by the central circadian pacemaker and the timely secretion of wake-promoting hormones. This setting dictates the onset of alertness, the timing of peak physical performance, and the duration of the wakeful period. A robustly set wake cycle is crucial for sustained energy and cognitive function.
Origin
This term is a conceptual and clinical descriptor in chronobiology, focusing on the active establishment of the diurnal phase. “Wake Cycle” refers to the period of activity, and “Setting” emphasizes the deliberate entrainment of the internal clock to the external environment. It is intrinsically linked to the early morning zeitgebers.
Mechanism
The master clock in the SCN is primarily set by the first strong light signal of the morning, which inhibits melatonin production and signals the start of the biological day. This signal drives the early morning rise of cortisol via the HPA axis, providing the hormonal foundation for wakefulness and metabolic activity. Consistently timed light exposure and meal intake reinforce this setting, ensuring the entire system is synchronized for optimal diurnal function.
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