Question 1

What is the Meaning of Voxel-Mirrored Homotopic Connectivity?

Accepted Answer

A highly specific neuroimaging metric derived from resting-state fMRI that quantifies the functional connectivity between corresponding brain regions in the left and right hemispheres. This measure assesses the degree of synchronization in spontaneous neuronal activity across the midline of the brain. It serves as a sensitive biomarker for the functional integrity of interhemispheric communication.

Question 2

What is the Origin of Voxel-Mirrored Homotopic Connectivity?

Accepted Answer

This is a complex, technical term from computational neuroscience and neuroimaging. It combines 'voxel' (a 3D pixel), 'mirrored' (referring to the symmetry across the midline), and 'homotopic connectivity' (connection between corresponding areas of the two hemispheres).

Question 3

What is the Mechanism of Voxel-Mirrored Homotopic Connectivity?

Accepted Answer

The metric is calculated by correlating the BOLD time series of a voxel in one hemisphere with its mirror-image voxel in the opposite hemisphere, indicating how synchronously they are communicating. High homotopic connectivity suggests strong, synchronized communication, which implies functional integrity between bilateral brain regions. Changes in this connectivity can be a sensitive biomarker for various neurological and hormonal disruptions affecting brain symmetry and coordination.

Voxel-Mirrored Homotopic Connectivity

Meaning

Origin

Mechanism

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