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Vitamin K2 Activation

Meaning

Vitamin K2 Activation refers to the essential biological process where the fat-soluble vitamin K2, specifically its menaquinone forms, acts as a crucial cofactor for the enzyme-mediated gamma-carboxylation of specific Vitamin K-dependent proteins (VKDPs). This post-translational modification is vital because it converts inactive VKDPs, such as osteocalcin in bone and Matrix Gla Protein (MGP) in the vasculature, into their biologically active forms capable of binding calcium. Proper activation is fundamental for maintaining skeletal integrity and actively preventing the pathological calcification of soft tissues and arteries.