What is the Origin of Vitamin D Status?

The term "Vitamin D" was coined in the early 20th century during the nutritional research into rickets, but its designation as a "secosteroid hormone" emerged later, recognizing its synthesis pathway and its action through a nuclear receptor (VDR) that regulates gene expression. "Status" refers to the current physiological level of this key regulator.

What is the Mechanism of Vitamin D Status?

Vitamin D, after being converted to its active form, 1,25-dihydroxyvitamin D, acts by binding to the Vitamin D Receptor (VDR), which is present in almost every cell type. The VDR complex then acts as a transcription factor, regulating the expression of hundreds of genes involved in calcium absorption, immune response, and the synthesis of key endocrine factors, thus exerting profound systemic influence.

Vitamin D Status

Meaning

The clinical measure of the concentration of 25-hydroxyvitamin D (25(OH)D) in the serum, which is the best indicator of the body’s total stores of this crucial fat-soluble secosteroid hormone. Vitamin D status is a vital biomarker, as optimal levels are essential not only for calcium homeostasis and bone health but also for modulating immune function, cell proliferation, and endocrine signaling across numerous tissues. Suboptimal status is a global health concern with systemic implications.

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Vitamin D Status

Meaning

Origin

Mechanism

Unlock Elite Performance through Micronutrients

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