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Vitamin D Signaling Pathways

Meaning

Vitamin D Signaling Pathways refer to the complex molecular cascade initiated by the active form of Vitamin D, calcitriol (1,25-dihydroxyvitamin D), binding to its cognate nuclear receptor, the Vitamin D Receptor (VDR), to regulate gene expression across numerous tissues. While classically known for calcium and bone homeostasis, these pathways are now understood to modulate hundreds of genes involved in immune function, cellular proliferation, hormonal synthesis, and metabolic regulation. Optimal signaling is critical for systemic health beyond skeletal integrity.