What is the Origin of Vitamin D Levels?

The term derives from the classification of Vitamin D as a fat-soluble vitamin and its subsequent discovery and recognition as a critical pro-hormone. The measurement of 25(OH)D became the standard clinical metric because it reflects both dietary intake and sun exposure and has a long circulating half-life.

What is the Mechanism of Vitamin D Levels?

Vitamin D, whether synthesized in the skin or ingested, is first hydroxylated in the liver to form 25(OH)D. This inactive form is then transported to the kidneys, where it undergoes a second hydroxylation catalyzed by the 1-alpha-hydroxylase enzyme to form the biologically active hormone, 1,25-dihydroxyvitamin D. This active form then binds to the Vitamin D Receptor (VDR) to regulate gene expression in target tissues, controlling calcium absorption and bone mineralization.

Vitamin D Levels

Meaning

Vitamin D Levels refer to the measurable concentration of 25-hydroxyvitamin D (25(OH)D) in the blood serum, which is the primary clinical indicator of a patient’s overall vitamin D status. Maintaining optimal levels is crucial for calcium and phosphate homeostasis, bone health, and a wide array of non-skeletal functions, including immune modulation and hormonal balance. Clinical practice uses these levels to diagnose deficiency, insufficiency, or toxicity and to guide appropriate supplementation.

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Vitamin D Levels

Meaning

Origin

Mechanism

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