This refers to the strategic clinical use of high-dose Vitamin C (ascorbic acid) to specifically enhance the function and resilience of the adrenal glands, which are central to the body’s stress response and steroid hormone production. The protocol is designed to replenish the high concentrations of this essential cofactor required for adrenal corticosteroid and catecholamine synthesis. This targeted support is vital for mitigating the systemic effects of chronic stress on the HPA axis.
Origin
The concept is rooted in biochemistry and endocrinology, stemming from the discovery that the adrenal cortex contains one of the highest concentrations of Vitamin C in the entire body. Its clinical application emerged from the understanding that prolonged stress rapidly depletes this reserve, significantly impairing optimal adrenal function. This depletion is a common clinical finding.
Mechanism
Vitamin C acts as a crucial cofactor for the enzymatic hydroxylation steps required in the biosynthesis of cortisol and other adrenal steroids from cholesterol. Furthermore, its potent antioxidant properties protect the adrenal gland from the oxidative stress generated during high-demand hormone production. Adequate supplementation ensures the adrenal glands can maintain a healthy output and an appropriate, modulated response to physiological stressors.
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