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VITAL Cohort Study

Meaning

The VITAL Cohort Study is a large-scale, randomized, double-blind, placebo-controlled clinical trial designed to definitively investigate the effects of supplemental vitamin D and omega-3 fatty acids on the primary prevention of major chronic diseases. This study enrolled a diverse population across the United States to provide robust, evidence-based data on the long-term health outcomes associated with these widely consumed supplements. The findings have profound implications for hormonal health, given vitamin D’s classification as a secosteroid and its pervasive influence on endocrine and metabolic function.