This refers to the information transmitted from the retina to the brain, encompassing both the visual perception of the environment and the non-visual signaling to the body’s master clock, the suprachiasmatic nucleus (SCN). This input is critical for synchronizing the circadian rhythm, which governs the timing of nearly all physiological processes, including the pulsatile release of hormones. The quality, spectrum, and timing of light entering the visual system are potent regulators of endocrine health.
Origin
The term is derived from neurobiology and chronobiology, distinguishing the purely sensory function of sight from the regulatory role of light on systemic physiology. It emphasizes that the eye is not merely an organ of vision but a crucial endocrine modulator. The ‘input’ highlights the external environmental signal driving internal biological timing.
Mechanism
Visual system input is received by two main pathways: the classic visual pathway for image formation and the non-visual pathway mediated by melanopsin-containing retinal ganglion cells (ipRGCs). The ipRGCs project directly to the SCN, communicating environmental light information. This light-dark signal then sets the timing for the HPA axis, the pineal gland’s melatonin production, and peripheral clocks throughout the body, thereby regulating the entire hormonal milieu.
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