Visfatin Resistin Levels refer to the circulating concentrations of two distinct, yet functionally related, adipokines—Visfatin (also known as Nicotinamide Phosphoribosyltransferase, or NAMPT) and Resistin—that are secreted primarily by visceral adipose tissue and immune cells. These levels serve as critical biomarkers for systemic inflammation, insulin resistance, and overall metabolic dysfunction. Elevated concentrations of both are often clinically correlated with an increased risk of type 2 diabetes and cardiovascular disease.
Origin
This term originates from the field of adipokine research and metabolic endocrinology, focusing on two specific protein messengers released by fat tissue. Visfatin was initially identified for its insulin-mimetic properties, while Resistin was named for its potential role in causing insulin resistance. Their measurement provides a “level” of insight into the inflammatory and dysfunctional state of adipose tissue.
Mechanism
Visfatin acts as an enzyme in NAD+ biosynthesis and can also function as a cytokine, potentially influencing insulin signaling and inflammation. Resistin, conversely, is strongly linked to promoting insulin resistance in peripheral tissues and enhancing pro-inflammatory cytokine production, contributing to a state of chronic low-grade inflammation. The measured levels of these adipokines reflect the secretory activity of the visceral fat depot, which is metabolically distinct and often more pathogenic than subcutaneous fat.
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