What is the Origin of Visceral Fat Sequestration?

This term is central to metabolic and cardiovascular medicine, distinguishing visceral fat from subcutaneous fat based on its anatomical location and profound negative endocrine impact. "Sequestration" is used to denote the harmful, concentrated nature of this fat deposition. Its clinical significance stems from epidemiological data linking increased visceral fat volume, often measured via DEXA or MRI, to insulin resistance and hypogonadism.

What is the Mechanism of Visceral Fat Sequestration?

Visceral fat accumulation is driven by a combination of chronic positive energy balance, genetic predisposition, and—critically—cortisol and sex hormone dysregulation. High cortisol levels promote the differentiation of pre-adipocytes into visceral fat cells, while declining testosterone in men and estrogen in women shifts fat deposition centrally. The fat cells then release free fatty acids directly into the portal circulation, overwhelming the liver and leading to systemic metabolic derangement.

Visceral Fat Sequestration ∞ Area

Visceral Fat Sequestration

Meaning

Visceral Fat Sequestration refers to the pathological accumulation and storage of adipose tissue deep within the abdominal cavity, surrounding the internal organs, which is a key marker of metabolic dysfunction and cardiovascular risk. This type of fat is metabolically active and secretes pro-inflammatory adipokines and hormones, fundamentally disrupting systemic insulin sensitivity and hormonal balance. Clinically, minimizing this sequestration is a critical goal for improving healthspan and reducing chronic disease risk.