Visceral Fat Programming refers to the long-term, often permanent, metabolic and endocrine phenotype established within abdominal adipose tissue, frequently programmed early in life.
Origin
This concept stems from the Developmental Origins of Health and Disease hypothesis applied specifically to adipocyte endocrinology.
Mechanism
The programming involves stable epigenetic alterations within adipocytes that dictate the chronic secretion profile of adipokines and inflammatory cytokines, thus impacting systemic insulin sensitivity.
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