Visceral Fat Mobilization is the process by which stored triglycerides within adipocytes surrounding the internal organs are hydrolyzed and released into the systemic circulation as free fatty acids (FFAs) for energy utilization elsewhere in the body. This crucial process is tightly regulated by the autonomic nervous system and key lipolytic hormones, such as catecholamines and growth hormone. Efficient and appropriate mobilization is vital for maintaining overall metabolic flexibility and health.
Origin
This term combines “visceral,” referring to the internal abdominal organs, with “mobilization,” signifying the controlled release from adipose tissue storage depots. It is a key concept in clinical endocrinology and energy balance research concerning ectopic fat distribution.
Mechanism
Mobilization is primarily initiated when hormone-sensitive lipase (HSL) is activated via phosphorylation, often through beta-adrenergic receptor stimulation or the direct metabolic action of growth hormone on adipocytes. This cascade leads to the breakdown of stored triglycerides into glycerol and FFAs, which then enter the peripheral bloodstream for use. Chronically elevated cortisol, however, can dysregulate this mechanism, sometimes promoting pathological visceral fat accumulation rather than appropriate mobilization under certain metabolic stressors.
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