What is the Origin of Visceral Fat Endocrine Signature?

This concept originates from metabolic medicine and endocrinology, following the recognition that adipose tissue is not merely a storage depot but a dynamic endocrine organ. The term emphasizes the specific, negative hormonal profile associated with visceral fat accumulation. Research demonstrated that this fat depot's location and its subsequent inflammatory output are more clinically relevant than overall body fat percentage.

What is the Mechanism of Visceral Fat Endocrine Signature?

The mechanism involves the chronic release of inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha, directly into the portal circulation, which leads to the liver. This inflammatory cascade disrupts hepatic insulin signaling, contributing to systemic insulin resistance. Furthermore, visceral fat alters the balance of adipokines like leptin and adiponectin, creating a state of hormonal dysregulation that perpetuates metabolic dysfunction and increases cardiovascular risk.

Visceral Fat Endocrine Signature ∞ Area

Visceral Fat Endocrine Signature

Meaning

The Visceral Fat Endocrine Signature refers to the unique and detrimental pattern of hormones and signaling molecules released by adipose tissue stored deep within the abdominal cavity, known as visceral fat. Unlike subcutaneous fat, visceral fat is highly metabolically active and acts as a dysfunctional endocrine organ, secreting pro-inflammatory adipokines and altering the body’s sensitivity to key metabolic hormones. This signature is a critical indicator of metabolic risk and systemic hormonal imbalance.