What is the Origin of Visceral Adiposity Pathophysiology?

This term is rooted in the clinical distinction between subcutaneous fat and visceral fat, following the realization that the anatomical location of fat storage has profoundly different health implications. The term "pathophysiology" emphasizes the disease-driving biological processes originating from this specific fat depot.

What is the Mechanism of Visceral Adiposity Pathophysiology?

The core mechanism involves the dysregulated release of adipokines, such as leptin and adiponectin, and the increased secretion of inflammatory cytokines, including TNF-alpha and Interleukin-6, directly into the portal circulation. These inflammatory mediators travel directly to the liver, impairing hepatic insulin signaling and promoting dyslipidemia. Furthermore, visceral fat often exhibits high aromatase activity, leading to increased peripheral conversion of androgens to estrogen, further disrupting the systemic hormonal milieu.

Visceral Adiposity Pathophysiology ∞ Area

Visceral Adiposity Pathophysiology

Meaning

Visceral Adiposity Pathophysiology refers to the specific biological mechanisms and functional consequences associated with the excessive accumulation of fat tissue around the internal organs within the abdominal cavity. This type of adiposity is not merely a storage issue; it is a highly metabolically active endocrine organ that secretes pro-inflammatory cytokines and hormones, driving systemic insulin resistance and cardiovascular risk. Understanding this pathophysiology is crucial for managing metabolic and hormonal health.