Visceral Adiposity Mobilization is the controlled catabolic process wherein stored triglycerides within the abdominal visceral fat depots are hydrolyzed and released into the circulation as free fatty acids for subsequent energy utilization by other tissues. Effective mobilization is essential for preventing ectopic lipid deposition and associated metabolic syndrome components. This process is tightly regulated by lipolytic hormones.
Origin
This term combines anatomical localization (“visceral adiposity”) with the kinetic process of release (“mobilization”), reflecting a focus on the metabolically active fat surrounding internal organs. Its significance increased with the understanding that visceral fat acts as an endocrine organ secreting pro-inflammatory adipokines, necessitating its targeted mobilization for improved systemic health. The term implies intentional, controlled release rather than passive turnover.
Mechanism
The primary mechanism involves the action of catecholamines and growth hormone, which bind to beta-adrenergic receptors on adipocytes, activating hormone-sensitive lipase (HSL). HSL then cleaves triglycerides into glycerol and fatty acids, which exit the adipocyte via fatty acid transporters. Insulin generally opposes this process; therefore, achieving successful mobilization requires a transient shift in the insulin-to-glucagon ratio favoring catabolism.
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