What is the Origin of Visceral Adiposity Mechanisms?

The term combines visceral adiposity, referring to fat surrounding the viscera, with mechanisms, indicating the underlying processes. This concept gained prominence in clinical medicine when epidemiological studies demonstrated the superior predictive power of visceral fat, compared to total body fat, for insulin resistance and cardiovascular disease.

What is the Mechanism of Visceral Adiposity Mechanisms?

The primary mechanism involves chronic hypercortisolemia and insulin resistance, which promote the differentiation of pre-adipocytes into visceral fat cells. Visceral fat cells exhibit a higher density of glucocorticoid receptors and are more resistant to the anti-lipolytic effects of insulin. Furthermore, they release inflammatory mediators, such as interleukin-6 and tumor necrosis factor-alpha, which directly impair hepatic insulin signaling and contribute to systemic metabolic dysfunction.

Visceral Adiposity Mechanisms

Meaning

Visceral adiposity mechanisms describe the complex physiological and molecular pathways that govern the preferential accumulation of adipose tissue around internal organs within the abdominal cavity. This form of central fat deposition is distinct from subcutaneous fat and is highly metabolically active, functioning as a dysregulated endocrine organ that secretes pro-inflammatory adipokines and alters systemic hormone sensitivity. Understanding these mechanisms is crucial for mitigating cardiometabolic risk.

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Visceral Adiposity Mechanisms

Meaning

Origin

Mechanism

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