What is the Origin of Visceral Adipose Signaling?

The term combines 'Visceral Adipose,' referring to the intra-abdominal fat compartment, with 'Signaling,' the molecular communication pathways. It stems from the recognition that adipose tissue is not merely an inert energy store but a highly active endocrine organ.

What is the Mechanism of Visceral Adipose Signaling?

Visceral fat cells, particularly when hypertrophic, secrete pro-inflammatory adipokines, such as TNF-alpha and Interleukin-6, which interfere with insulin receptor signaling in the liver and muscle. They also secrete hormones like leptin and resistin, disrupting satiety and glucose homeostasis. This chronic inflammatory and endocrine output creates a state of systemic insulin resistance and contributes to the dysregulation of sex and adrenal hormones.

Visceral Adipose Signaling

Meaning

The complex endocrine and paracrine communication originating from the metabolically active fat tissue that is centrally located around the abdominal organs. This signaling involves the secretion of various adipokines, cytokines, and hormones, which profoundly influence systemic inflammation, insulin sensitivity, and overall metabolic health. Excessive visceral adipose signaling is a primary driver of chronic metabolic disease and hormonal dysregulation.