What is the Origin of Virilization in Women?

The term is derived from the Latin word virilis, meaning masculine or manly, combined with the suffix "-ization," denoting a process of becoming. In endocrinology, it describes the pathological shift in phenotype toward a male pattern, which is a clear sign of significant androgen excess or hypersensitivity.

What is the Mechanism of Virilization in Women?

The underlying mechanism is the sustained elevation of free androgens, such as testosterone and dihydrotestosterone (DHT), which bind to and activate androgen receptors in target tissues like hair follicles, muscle, and the larynx. Common etiological factors include polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia, or androgen-secreting tumors. The clinical presentation is a direct result of the androgenic signaling overpowering the normal physiological effects of endogenous estrogens.

Virilization in Women ∞ Area

Virilization in Women

Meaning

Virilization in Women is a clinical syndrome characterized by the development of male-pattern secondary sexual characteristics due to an excess of circulating androgens. The clinical manifestations can include hirsutism, temporal balding, deepening of the voice, clitoromegaly, and increased muscle mass. This condition represents a significant disruption of the delicate endocrine balance, requiring prompt diagnostic evaluation to identify the underlying source of androgen overproduction.