Vigor biomarkers are a collection of measurable biological indicators that collectively reflect an individual’s state of robust health, functional energy, and physiological resilience, often extending beyond traditional disease-focused lab values. These markers typically include optimal ranges for sex hormones, specific metabolic ratios, inflammatory markers, and indicators of mitochondrial function. Monitoring these biomarkers provides an objective assessment of an individual’s subjective feeling of vitality.
Origin
This is a conceptual term used in preventative and longevity medicine, combining the qualitative feeling of ‘vigor’ (physical strength and good health) with the quantitative precision of ‘biomarkers.’ It represents a shift in clinical focus from pathology to the measurement and optimization of high-level health and functional capacity.
Mechanism
These biomarkers function as readouts of the body’s core homeostatic processes. For instance, an optimal free testosterone to cortisol ratio, low C-reactive protein, and high NAD+ levels all contribute to the physiological state associated with vigor. By tracking and optimizing this panel, clinicians are directly managing the underlying neuroendocrine, metabolic, and immune processes that govern energy and resilience.
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