Question 1

What is the Meaning of Vermeulen Equation?

Accepted Answer

The Vermeulen Equation is a validated mathematical formula, developed by Dr. Alex Vermeulen and colleagues, utilized in clinical endocrinology to accurately estimate the concentration of free, biologically active testosterone in the circulation. This calculation uses the measured values of total testosterone, Sex Hormone-Binding Globulin (SHBG), and albumin.

Question 2

What is the Origin of Vermeulen Equation?

Accepted Answer

The equation is named after its principal investigator, reflecting a critical advancement in the precise clinical assessment of androgen status. It arose from the physiological necessity to determine the unbound fraction of testosterone, as only this fraction can freely diffuse into cells and exert its biological effects.

Question 3

What is the Mechanism of Vermeulen Equation?

Accepted Answer

The formula applies the established principles of mass action and equilibrium dialysis to calculate the free hormone concentration based on the known, documented binding affinities of testosterone to both the high-affinity SHBG and the lower-affinity albumin protein. Utilizing this calculation provides a more precise and physiologically relevant assessment of androgen deficiency or excess than relying solely on the less informative total testosterone level, which is essential for guiding precision hormone replacement therapy.

Vermeulen Equation

Meaning

Origin

Mechanism

What Is the Difference between Testing Total Testosterone and Free Testosterone after a Lifestyle Change?

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