Question 1

What is the Meaning of Venetoclax?

Accepted Answer

Venetoclax is a highly targeted, small-molecule chemotherapy drug classified as a BCL-2 inhibitor, primarily used in the clinical treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). Its mechanism of action is to selectively induce apoptosis, or programmed cell death, in cancer cells that rely on the BCL-2 protein for survival. While not a direct hormonal therapy, its use is relevant in the health and longevity space as an example of precision medicine targeting cell survival pathways.

Question 2

What is the Origin of Venetoclax?

Accepted Answer

The term is a proprietary name for the compound developed by pharmaceutical research, a modern example of rational drug design based on molecular biology. The origin of its function lies in the detailed understanding of the BCL-2 family of proteins, which are critical regulators of the mitochondrial pathway of apoptosis. Its development represents a significant advance in molecular oncology.

Question 3

What is the Mechanism of Venetoclax?

Accepted Answer

The BCL-2 protein normally acts to inhibit apoptosis, keeping cancer cells alive. Venetoclax functions as a BH3 mimetic, binding directly to the BCL-2 protein and neutralizing its anti-apoptotic effect. This inhibition releases pro-apoptotic proteins, such as BIM, which then trigger the mitochondrial outer membrane permeabilization, leading to the release of cytochrome c and the activation of the caspase cascade, ultimately resulting in the selective death of the malignant cells.

Venetoclax

Meaning

Origin

Mechanism

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