What is the Origin of VEGF Upregulation?

The term is rooted in molecular biology and vascular research, stemming from the discovery and characterization of VEGF in the late 1980s as a primary mediator of angiogenesis. "Upregulation" is the biological term for increasing the number of receptors or the rate of synthesis of a protein. This mechanism is often targeted in regenerative medicine and cardiovascular health.

What is the Mechanism of VEGF Upregulation?

Upregulation is typically triggered by local tissue hypoxia or by the signaling cascade initiated by specific growth factors or peptides, which bind to cell surface receptors like VEGFR-2 on endothelial cells. This binding activates intracellular pathways that ultimately lead to the transcription and

VEGF Upregulation

Meaning

VEGF Upregulation refers to the biological process of increasing the expression and activity of Vascular Endothelial Growth Factor (VEGF), a potent signaling protein that stimulates the formation of new blood vessels (angiogenesis). This process is vital for tissue repair, wound healing, and enhancing the delivery of oxygen and nutrients to metabolically active tissues, such as muscle and brain. Targeted upregulation is a strategy used to improve circulation and support tissue vitality.