What is the Origin of VEGF Signaling?

The term originates from molecular biology and vascular physiology, following the isolation and characterization of VEGF as a potent and specific mitogen for endothelial cells. Its role in wound healing and tumor biology established its clinical significance. The connection to endocrinology is evident in its regulation by hormones, underscoring the interplay between systemic endocrine signals and localized vascular remodeling.

What is the Mechanism of VEGF Signaling?

Upon VEGF binding, the receptor dimerizes and activates its intrinsic tyrosine kinase domain, initiating a phosphorylation cascade that leads to the transcription of pro-angiogenic genes. Estrogen, for example, is known to upregulate VEGF expression, contributing to the cyclical vascular changes in the endometrium. This signaling is tightly regulated because excessive or aberrant activation can contribute to pathological conditions like diabetic retinopathy or the vascularization of tumors, whereas insufficient signaling impairs tissue repair.

VEGF Signaling ∞ Area

VEGF Signaling

Meaning

VEGF Signaling refers to the complex biochemical pathway initiated by the binding of Vascular Endothelial Growth Factor (VEGF) to its specific receptor tyrosine kinases on the surface of endothelial cells. This signaling cascade is the principal physiological driver of angiogenesis, the formation of new blood vessels from pre-existing vasculature, a process vital for tissue repair, growth, and development. Within the hormonal domain, this pathway is modulated by various steroids and is crucial for the vascularization of reproductive tissues and the maintenance of a healthy metabolic environment.