What is the Origin of VEGF Receptor 2?

This is a standard, precisely named molecular entity in biochemistry and cell biology, identified as researchers mapped the signaling pathways of growth factors in the 1990s. The name clearly denotes its ligand (VEGF) and its classification as a receptor.

What is the Mechanism of VEGF Receptor 2?

Upon binding of the VEGF ligand, VEGFR2 undergoes dimerization and subsequent autophosphorylation of its intracellular tyrosine residues, initiating a complex intracellular signaling cascade. This cascade activates pathways like the PI3K/Akt and MAPK pathways, which ultimately lead to the transcription of genes necessary for endothelial cell proliferation, migration, and the structural organization of new capillaries. Its function is tightly regulated to ensure proper vascular growth without pathological overgrowth.

VEGF Receptor 2 ∞ Area

VEGF Receptor 2

Meaning

Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), a high-affinity transmembrane tyrosine kinase receptor that is primarily expressed on the surface of endothelial cells, which line the interior of blood vessels. It is the principal receptor responsible for mediating the powerful pro-angiogenic signals of VEGF, driving the proliferation, migration, and survival of endothelial cells, which is essential for the formation of new blood vessels (angiogenesis). This receptor is crucial for wound healing and tissue perfusion.