Vasopressin Regulation is the intricate homeostatic control system that governs the synthesis, secretion, and action of Arginine Vasopressin (AVP), also known as Antidiuretic Hormone (ADH). This regulatory process is paramount for maintaining the body’s fluid balance, plasma osmolarity, and blood pressure. Dysregulation of this system can lead to disorders of water balance, such as diabetes insipidus or the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Origin
The term is a core concept in neuroendocrinology and renal physiology, stemming from the discovery of AVP’s dual actions as a vasoconstrictor and a water-retaining hormone. The regulatory system is centered in the hypothalamus and posterior pituitary gland.
Mechanism
The primary mechanism involves osmoreceptors in the hypothalamus detecting small increases in plasma osmolarity, which then stimulate the neurosecretory cells to release AVP from the posterior pituitary into the circulation. AVP subsequently acts on V2 receptors in the renal collecting ducts, triggering the insertion of aquaporin-2 water channels into the apical membrane. This action increases water reabsorption back into the bloodstream, effectively diluting the plasma and restoring osmotic balance.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.