What is the Origin of Vascular Risk Factors?

This concept is a core element of preventative cardiology and internal medicine, derived from large-scale epidemiological studies that identified modifiable contributors to atherosclerotic disease. In the hormonal wellness space, the origin is linked to the impact of endocrine imbalances, such as cortisol excess or estrogen deficiency, on endothelial function and metabolic health. The term provides a framework for clinical risk stratification.

What is the Mechanism of Vascular Risk Factors?

These factors collectively damage the vascular endothelium, leading to arterial stiffness, plaque formation (atherosclerosis), and reduced nitric oxide bioavailability. This pathology compromises blood flow and oxygen delivery to vital organs, including the brain, contributing to chronic ischemia and microvascular damage. Furthermore, poor vascular health impairs the propulsive force required for efficient neurovascular clearance, exacerbating the accumulation of neurotoxic waste products.

Vascular Risk Factors ∞ Area

Vascular Risk Factors

Meaning

Vascular Risk Factors are the measurable physiological and lifestyle variables that significantly increase an individual’s probability of developing cardiovascular, cerebrovascular, and peripheral artery diseases. These factors include hypertension, dyslipidemia, insulin resistance, chronic inflammation, and smoking. Clinically, the aggregation of these risks is a major predictor of overall mortality and morbidity, especially neurocognitive decline.