What is the Origin of Vascular Endothelial Integrity?

This concept is central to cardiovascular physiology, recognizing the endothelium as a crucial endocrine organ that regulates vascular homeostasis. Loss of integrity is the earliest detectable event in the pathogenesis of atherosclerosis and other vascular diseases. The focus on "integrity" highlights the importance of the barrier function and the endothelium's signaling capabilities.

What is the Mechanism of Vascular Endothelial Integrity?

Integrity is maintained by the balanced production of vasoactive substances, notably the potent vasodilator Nitric Oxide (NO) and vasoconstrictors like endothelin-1. Hormones, including estrogen and testosterone, exert protective effects by promoting NO bioavailability and reducing oxidative stress on the endothelial cells. Dysfunction occurs when chronic inflammation or metabolic stress impairs NO production and increases endothelial permeability.

Vascular Endothelial Integrity

Meaning

The state of optimal structural and functional health of the endothelium, the single-cell layer lining all blood and lymphatic vessels. Integrity is defined by the endothelium’s capacity to regulate vascular tone, prevent platelet aggregation, and maintain a non-inflammatory barrier between the blood and vessel wall. Preserving this integrity is paramount for cardiovascular health and systemic circulation.