What is the Origin of Vascular Dysfunction?

The term combines "vascular," referring to the blood vessels, and "dysfunction," indicating abnormal or impaired function. Its clinical focus intensified with the realization that the endothelium is not merely a passive barrier but a dynamic endocrine organ critical for circulatory health.

What is the Mechanism of Vascular Dysfunction?

Vascular dysfunction operates when the endothelium fails to produce sufficient nitric oxide (NO), a potent vasodilator, or when the balance between vasodilating and vasoconstricting factors is disrupted. Hormonal factors, such as low testosterone or high levels of inflammatory cytokines driven by metabolic syndrome, can directly impair endothelial cell signaling, leading to chronic vasoconstriction and increased arterial stiffness.

Vascular Dysfunction

Meaning

An impairment in the normal physiological function of the blood vessels, particularly the endothelium, which is the inner lining of the arteries. This dysfunction is characterized by a reduced ability of the blood vessels to properly dilate (vasodilation) and regulate blood flow, representing an early and critical step in the development of atherosclerosis and cardiovascular disease. It is often exacerbated by hormonal imbalances.