What is the Origin of Val158Met Genotype?

The name precisely describes the genetic change: "Val158Met" indicates the amino acid substitution at position 158, and "Genotype" refers to the specific genetic makeup at that locus. This SNP is a classic example of how genetic variation influences detoxification capacity.

What is the Mechanism of Val158Met Genotype?

The Val158Met substitution affects the COMT enzyme's ability to efficiently methylate its substrates, including the potentially harmful 2- and 4-hydroxyestrogens. The Met/Met genotype is associated with a 3- to 4-fold decrease in COMT activity compared to the Val/Val genotype, leading to slower methylation and potentially higher circulating levels of reactive estrogen metabolites. This reduced clearance capacity is a key consideration in personalized hormone management.

Val158Met Genotype ∞ Area

Val158Met Genotype

Meaning

A common single nucleotide polymorphism (SNP) located at codon 158 of the Catechol-O-Methyltransferase (COMT) gene, resulting in a substitution of the amino acid valine (Val) with methionine (Met). This genetic variation is highly significant in hormonal health because it dictates the thermal stability and enzymatic activity of the COMT enzyme. The genotype influences the rate of catecholestrogen detoxification and neurotransmitter breakdown.