What is the Origin of V2 Receptor?

The receptor was named based on its high affinity for vasopressin and its designation as the second distinct vasopressin receptor type to be pharmacologically characterized. Vasopressin itself was isolated and its functions studied in the mid-20th century, leading to the eventual identification and cloning of its various receptor subtypes, V1a, V1b, and V2. The term is firmly rooted in classical endocrinology and renal physiology, defining a key mechanism of fluid homeostasis.

What is the Mechanism of V2 Receptor?

Upon binding of AVP, the V2 receptor couples to the Gs protein, which stimulates adenylyl cyclase, leading to a rapid increase in intracellular cyclic AMP (cAMP). This rise in cAMP activates Protein Kinase A (PKA), which then phosphorylates aqu

V2 Receptor

Meaning

The V2 Receptor, officially known as the Vasopressin Receptor 2, is a G protein-coupled receptor primarily located in the principal cells of the renal collecting ducts in the kidney. Its paramount physiological function is to mediate the powerful antidiuretic effects of the hormone arginine vasopressin (AVP), also known as antidiuretic hormone (ADH). Activation of this receptor is crucial for regulating the body’s water balance, facilitating water reabsorption, and thereby maintaining plasma osmolality and blood pressure. Dysfunction of the V2 receptor or its signaling pathway is the underlying cause of nephrogenic diabetes insipidus.