What is the Origin of UVB Phototherapy?

The term combines "UVB," the specific spectrum of ultraviolet light, with "phototherapy," meaning treatment using light. Its origin lies in dermatology and photobiology, recognizing the biological effects of sunlight on the skin, including the well-known pathway for Vitamin D production. Narrowband UVB (NB-UVB) is a modern refinement of this therapeutic modality.

What is the Mechanism of UVB Phototherapy?

The primary mechanism involves the absorption of UVB photons by cutaneous chromophores. In the context of hormonal health, UVB exposure converts 7-dehydrocholesterol in the skin into pre-vitamin D3, which then isomerizes to Vitamin D3, a critical pro-hormone. Furthermore, the radiation exerts local anti-inflammatory effects by modulating immune cell function and suppressing aberrant cellular proliferation, offering relief in conditions like psoriasis.

UVB Phototherapy ∞ Area

UVB Phototherapy

Meaning

UVB Phototherapy is a clinical intervention utilizing specific wavelengths of ultraviolet B radiation, typically between 290 and 320 nanometers, to treat various dermatological conditions and to stimulate the endogenous synthesis of Vitamin D in the skin. This controlled exposure to non-ionizing radiation leverages its anti-inflammatory and immunomodulatory effects for therapeutic benefit. The dosage and duration of exposure are precisely regulated to maximize clinical benefit while minimizing adverse effects.