What is the Origin of Urogenital Atrophy?

The term is descriptive, combining urogenital, referring to the urinary and reproductive systems, and atrophy, meaning a wasting away or decrease in size and function. The condition is directly linked to the physiological decline of ovarian estrogen production during the menopausal transition.

What is the Mechanism of Urogenital Atrophy?

The primary mechanism is the profound loss of estrogenic stimulation to the estrogen-dependent tissues of the lower genital and urinary tracts. Estrogen is crucial for maintaining the vascularity, collagen content, elasticity, and glycogen production of the vaginal epithelium, which supports a healthy, acidic microbiome. Without adequate estrogen, the tissues become thin, less elastic, and poorly lubricated, and the vaginal pH rises, leading to the clinical manifestations of atrophy and increased susceptibility to infection and trauma.

Urogenital Atrophy

Meaning

Urogenital Atrophy, also clinically termed Genitourinary Syndrome of Menopause (GSM), is a collection of signs and symptoms resulting from the hypoestrogenic state associated with menopause, affecting the labia, clitoris, vagina, urethra, and bladder. The condition is characterized by thinning, drying, and inflammation of the vaginal and lower urinary tract tissues due to estrogen deprivation. Symptoms often include vaginal dryness, irritation, pain during intercourse (dyspareunia), and recurrent urinary tract infections, significantly impacting a woman’s quality of life and sexual health.

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Urogenital Atrophy

Meaning

Origin

Mechanism

What Are the Clinical Guidelines for Female Hormone Optimization?

How Do Aromatase Inhibitors Influence Testosterone Therapy Protocols for ER+ Breast Cancer?

What Are the Physiological Consequences of Interrupting Hormone Replacement Therapy?

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