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UGT2B15

Meaning

UGT2B15 is the abbreviation for Uridine 5′-diphospho-glucuronosyltransferase 2B15, a crucial enzyme belonging to the UGT superfamily that is instrumental in the metabolic clearance of steroid hormones and other lipophilic compounds. This enzyme catalyzes the glucuronidation reaction, which significantly increases the water solubility of its substrates, thereby facilitating their efficient excretion via the urine or bile. Genetic polymorphisms in the UGT2B15 gene can substantially alter the metabolic rate of key androgens, impacting their bioavailability and clinical effects.