What is the Origin of UGT1A4?

The term is the standardized nomenclature for the gene and its resulting enzyme, UGT1A4, a component of the UGT1A gene cluster located on chromosome 2. This enzyme is central to the field of pharmacogenetics and hormonal biotransformation, as genetic polymorphisms in this enzyme can significantly alter drug and hormone metabolism rates. Its function is fundamental to the body's ability to excrete fat-soluble substances efficiently.

What is the Mechanism of UGT1A4?

UGT1A4 functions by covalently linking a molecule of glucuronic acid, derived from UDP-glucuronic acid, to a hydroxyl or amino group on the target steroid or drug molecule. This critical process, known as glucuronidation, dramatically increases the compound's polarity and water solubility. The resulting glucuronide conjugate is then readily excreted from the body via the bile or urine, effectively terminating the biological activity of the original substrate.

UGT1A4

Meaning

UGT1A4 is a specific isoform of the Uridine Diphosphate-Glucuronosyltransferase enzyme family, playing a critical and specific role in the Phase II detoxification pathway in the liver. This enzyme catalyzes the glucuronidation of various endogenous and exogenous lipophilic compounds, including a number of key steroid hormones and certain therapeutic drugs. The specific activity of UGT1A4 is a key determinant in the metabolic clearance rate and half-life of its numerous substrates.

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UGT1A4

Meaning

Origin

Mechanism

Are There Non-CYP19A1 Genetic Markers Influencing Aromatase Inhibitor Efficacy?

How Do Individual Metabolic Differences Influence Aromatase Inhibitor Response?

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