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UGT1A1

Meaning

UGT1A1 stands for Uridine Diphosphate Glucuronosyltransferase 1A1, a crucial enzyme belonging to the Phase II detoxification system primarily expressed in the liver. This enzyme plays a vital role in the metabolism and clearance of various endogenous and exogenous compounds, including bilirubin and a significant portion of circulating steroid hormones, particularly estrogens. Genetic polymorphisms in the UGT1A1 gene can lead to reduced enzyme activity, potentially slowing the detoxification of estrogen metabolites and influencing hormonal health outcomes. Clinical attention to this enzyme’s function is key in personalized hormone therapy and risk assessment.