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Ubiquitin Proteasome System Inhibition

Meaning

Ubiquitin Proteasome System Inhibition is the targeted modulation, either pharmacological or nutritional, that temporarily reduces the activity of the Ubiquitin Proteasome System (UPS), a major cellular pathway responsible for the regulated degradation of misfolded or unneeded proteins. While the UPS is essential for protein quality control, its excessive activity can pathologically contribute to the loss of muscle mass, a condition known as sarcopenia. Strategic, controlled inhibition is sometimes employed in clinical settings to promote an anabolic environment and preserve critical musculoskeletal integrity.